Mechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes (Agilent expression data)

ABSTRACT: Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of hundreds of genes, it provides a powerful biological system to elucidate the molecular strategies that underlie signal- and time-dependent transitions of gene expression. Using a combination of genome-wide and gene-specific approaches, we provide evidence that rather than representing off/on transitions, Toll-like receptor 4 (TLR4)-dependent activation of nearly all immediate/early (I/E) and late response genes results from a sequential process in which signal-independent factors, exemplified by Gabpa, initially establish basal levels of gene expression that are then amplified by signal-depende

ORGANISM(S): Mus musculus

SUBMITTER: Christopher Benner 

PROVIDER: E-GEOD-23620 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress