RCC cell lines and paired tumors
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Venkata Thodima
PROVIDER: E-GEOD-23631 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genomic deregulation during metastasis of renal cell carcinoma implements a myofibroblast-like program of gene expression.
López-Lago Miguel A MA Thodima Venkata J VJ Guttapalli Asha A Chan Timothy T Heguy Adriana A Molina Ana M AM Reuter Victor E VE Motzer Robert J RJ Chaganti Raju S K RS
Cancer research 20101015 23
Clear cell renal cell carcinoma (RCC) is the most common and invasive adult kidney cancer. The genetic and biological mechanisms that drive metastatic spread of RCC remain largely unknown. We have investigated the molecular signatures and underlying genomic aberrations associated with RCC metastasis, using an approach that combines a human xenograft model; expression profiling of RNA, DNA, and microRNA (miRNA); functional verification; and clinical validation. We show that increased metastatic a ...[more]
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