Genome-wide analysis of autosomal sex differences in human DNA methylome

ABSTRACT: Sex difference had been implicated in pathophysiology and prognosis of common diseases, such as acute lymphoblastic leukemia and coronary heart disease. It is well known that the disease phenotype is shaped by the interaction between the environment, genome, and epigenome. The environmental and the genetic components were extensively studied in the past. Unlike the formers, the role of epigenetics has only been recently investigated. To date, little has been known about differences in epigenetic makeup between the two sexes. Here we present a genome-wide study of sex-specific differences in DNA methylation in healthy individuals. We compared the methylation status of ~26,000 CpGs in the promoter of ~14,000 genes between age-matched males (n=12) and females (n=12). We identified 19 CpGs in

ORGANISM(S): Homo sapiens

SUBMITTER: Rosanna Weksberg 

PROVIDER: E-GEOD-23638 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress