Poly(ADP-ribose) polymerase 3: a key regulator of ectodermal specification and neural crest development.

ABSTRACT: Poly(ADP-ribose) polymerase 3 (PARP3) is a member of the PARP family of enzymes. It is structurally related to the well characterized type member PARP1 that orchestrates DNA strand break repair and cell death by the synthesis of poly(ADP-ribose). In contrast, the functions of PARP3 are undefined. We have used several in vitro and in vivo approaches to examine the possible functions of PARP3 as a transcriptional regulator, a function suggested from its previously reported association with several Polycomb group (PcG) proteins. A ChIP-chip analysis of PARP3 gene occupancy in the human neuroblastoma cell line SK-N-SH reveals that PARP3 is preferentially associated with developmental genes and is significantly enriched around the transcriptional start site of several genes encoding neuronal an

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Paquet 

PROVIDER: E-GEOD-23709 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress