Effect of Maternal Separation on DOI-induced transcriptome

ABSTRACT: Depression is a heterogeneous disorder characterized by a wide range of symptoms, including but not restricted to increased anxiety-like behavior, altered stress responsivity, increased depressive like behavior, decreased pleasure seeking, and altered susceptibility to drugs of abuse. Adding another level of complexity to the disease is the fact that individuals differ in their susceptibility to depression. Research done over the past decade has highlighted the contribution of early life adverse experience to this individual differences in vulnerability to depression. Such studies have been done at the clinical as well as the preclinical level, where rodent and primate models of adverse postnatal environment such as Maternal Separation (MS) are used. MS involves separation of the pup from

ORGANISM(S): Rattus norvegicus

SUBMITTER: Madhurima Benekareddy 

PROVIDER: E-GEOD-23728 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress