Bystander response to 2.5 Gy of protons in a human 3-dimensional skin model in 16 h after exposure

ABSTRACT: Bystander mechanisms that originate in the areas surrounding a tissue damage presumably play an important role participating in wound healing and tissue remodeling. Thus, identification and characterization of bystander mechanisms will help to development of new treatments of patients with a radiation exposure. In the present study, we irradiated 3-dimensional tissue model of human epidermis, Epi-200 (Mat-Tek, Ashland, MA), with 2.5 Gy protons. By exposing only a thin strip across the center of the EPI-200 tissue, we have been able to measure global gene expression responses in directly irradiated and bystander cells located at 0.125-0.375, 0.375-0.625, 0.625-875 mm from the irradiation line. The data were analyzed using BRB-Array Tools (NIH), and further gene ontology analysis and network

ORGANISM(S): Homo sapiens

SUBMITTER: Alexandre Mezentsev 

PROVIDER: E-GEOD-23803 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress