Biological response to 2.5 Gy of X-rays in 3-dimensional skin model, Epi-200.

ABSTRACT: Biological response X-rays traditionally serves as a standard in comparative analysis of different qualities of ionizing radiation. Most such studies have utilized 2-dimensional culture systems, which may not fully represent responses in 3-dimensional tissues. To gain insight into biological responses to X-rays in tissue, we have profiled global gene expression in EPI-200, a 3-dimensional tissue model that imitates the structure and function of human epidermis, at 4, 16 and 24 hours after exposure to 2.5 Gy of X-rays. The most significant gene ontology groups were associated with cell cycle, cytokinesis, establishment and maintenance of chromatin architecture. Remarkably, genes with a role in cell cycle were predominantly downregulated at all time points while genes involved in the cell de

ORGANISM(S): Homo sapiens

SUBMITTER: Alexandre Mezentsev 

PROVIDER: E-GEOD-23807 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress