Endogenous MicroRNA Activity Is Not Affected Following Infection With MicroRNA Controlled Adenovirus

ABSTRACT: Replicating viruses have broad applications in biomedicine, notably in cancer virotherapy and in the design of attenuated vaccines, however uncontrolled virus replication in vulnerable tissues can give pathology and often restricts the use of potent strains. Increased knowledge of tissue-selective microRNA expression now affords the possibility of engineering replicating viruses that are attenuated at the RNA level in sites of potential pathology, but retain wild type replication activity at sites not expressing the relevant microRNA. To assess the usefulness of this approach for the DNA virus, adenovirus, we have engineered a hepatocyte-safe wild type adenovirus 5 (Ad5), which normally mediates significant toxicity and is potentially lethal in mice. To do this we have included binding s

ORGANISM(S): Mus musculus

SUBMITTER: Dilair Baban 

PROVIDER: E-GEOD-23854 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress