Anti-microbial peptides increase tolerance to oxidant stress in Drosophila melanogaster

ABSTRACT: It is well appreciated that reactive oxygen species (ROS) are deleterious to mammals, including humans, especially when generated in abnormally large quantities from cellular metabolism. Whereas the mechanisms leading to the production of ROS are rather well delineated, the mechanisms underlying tissue susceptibility or tolerance to oxidant stress remain elusive. Through an experimental selection over many generations, we have previously generated Drosophila melanogaster flies that tolerate tremendous oxidant stress and have shown that the family of antimicrobial peptides (AMP) is over-represented in these tolerant flies. Furthermore, we have also demonstrated that overexpression of even one AMP at a time (e.g. Diptericin) allows wild type flies to survive much better in hyperoxia. In the

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Dan Zhou 

PROVIDER: E-GEOD-23902 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress