Isolation and characterization of progenitor-like cells from human renal proximal tubules

ABSTRACT: The adult kidney has a remarkable capacity for self-renewal upon damage. Whether this regeneration is mediated by dedifferentiating surviving cells or as recently suggested by stem cells has not been unequivocally settled. The stem cell concept is however hampered by lack of consensus regarding the histological localization of and defining markers for these cells. Here, we demonstrate that aldehyde dehydrogenase (ALDH) activity may be used for isolation of cells with progenitor-like characteristics from adult human renal cortical tissue. Gene expression profiling of the isolated ALDHhigh and ALDHlow cell fractions followed by immunohistochemical interrogation of renal tissues enabled us to delineate a tentative progenitor cell population with a scattered distribution in the epithelial laye

ORGANISM(S): Homo sapiens

SUBMITTER: Martin Johansson 

PROVIDER: E-GEOD-23911 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress