Whole genome gene expression modifications associated with micronucleus formation in blood cells from nitrosamine-exposed humans

ABSTRACT: N-nitroso compounds (NOCs) can be formed through endogenous nitrosation in the human body and are known to induce micronuclei (MN) formation in vitro. Since lymphocytic MN represent a well-validated biomarker of effect with regard to carcinogenic risk in multiple target organs, establishing a link between NOCs and MN in humans could provide evidence for a carcinogenic risk. Investigating gene expression modulations in relation to NOC exposure could provide further crucial information on underlying molecular mechanisms-of-action. The purpose of this study is therefore to establish the relationship between human NOC exposure under daily life conditions and MN formation in relation to associated transcriptomic changes, using lymphocytes as a surrogate tissue for analyzing carcinogenic events

ORGANISM(S): Homo sapiens

SUBMITTER: Dennie Hebels 

PROVIDER: E-GEOD-23919 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress