Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Natalia Shulzhenko
PROVIDER: E-GEOD-23934 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut.
Shulzhenko Natalia N Morgun Andrey A Hsiao William W Battle Michele M Yao Michael M Gavrilova Oksana O Orandle Marlene M Mayer Lloyd L Macpherson Andrew J AJ McCoy Kathy D KD Fraser-Liggett Claire C Matzinger Polly P
Nature medicine 20111120 12
Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium and the microbiota. We found that, in the absence of B cells, or of IgA, and in the presence of the microbiota, the intestinal epithelium launches its own protective mechanisms, upregulating interferon-inducible immune response pathways and simultaneously repressing Gata4-related metabolic functions. This shift in intestinal function leads to lipid malabsorpt ...[more]
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