Leptin dependent control of testosterone regulated hepatic lipid metabolism

ABSTRACT: Population based studies have established that androgen deficiency in males correlates with type 2 diabetes, visceral adiposity, and metabolic syndrome. Androgen therapy has been investigated as a possible treatment regime to combat these disorders. However, the molecular mechanism of androgen effects on these diseases still remain poorly understood. The zucker diabetic fatty (ZDF) rat, containing a mutation in the leptin receptor, is a well-investigated model of obesity and type 2 diabetes. Male rats are characterized as androgen deficient and spontaneously develop obese, hyperlipidemia, hyperglycemia and hyperinsulinemia. In this study, we used ZDF male rats as a model of metabolic syndrome to investigate the effects of testosterone administration on the development of the metabolic cond

ORGANISM(S): Rattus norvegicus

SUBMITTER: Carolina Gustavsson 

PROVIDER: E-GEOD-23941 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress