Apoptosis, autophagy and senescence protect BRAFV600E nevi from malignant transformation

ABSTRACT: The oncogenic mutation BRAFV600E is a common event in nevi and melanomas, which are aggressive skin tumors characterized by MAPK signaling pathway activation. It has been observed that mutated benign melanocytic lesions can remain unchanged for decades, but also proliferate or undergo oncogene-induced senescence. The purpose of this study was to investigate the presence of a gene expression signature in BRAFV600E mutated nevi compared to wild-type ones, all derived from sun exposed sites. Microdissected tissues from excisional biopsies of acquired nevi were analyzed to detect the presence of BRAF and NRAS mutations and to profile whole genome expression by means of oligonucleotide microarrays. BRAFV600E mutation was evidenced in 64% of nevi, while no NRAS mutations were detected. Functio

ORGANISM(S): Homo sapiens

SUBMITTER: giovanna chiorino 

PROVIDER: E-GEOD-23976 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress