Short-term exposure to effluent from bulk drug industries

ABSTRACT: The Patancheru area near Hyderabad in India is recognized as a key link in the global supply chain for many bulk drugs. A central treatment plant receives wastewater from about 90 different manufacturers and the resulting complex effluent has contaminated surface, ground and drinking water in the region. Ecotoxicological testing of the effluent has shown adverse effects for several organisms, including aquatic vertebrates. In an attempt to start investigating how exposure to effluent-contaminated water may affect humans and other terrestrial vertebrates, rats were tube-fed effluent. Results from microarray and quantitative polymerase chain reaction assays indicated, however, no marked effects on hepatic gene expression after five days exposure. Neither did a clinical analysis of blood seru

ORGANISM(S): Rattus norvegicus

SUBMITTER: Erik Kristiansson 

PROVIDER: E-GEOD-23983 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress