Mapping the binding regions of the cubitus interruptus (Ci) activator form

ABSTRACT: Paracrine Hedgehog (Hh) signaling regulates growth and patterning in many Drosophila organs. We mapped chromatin binding sites for Cubitus interruptus (Ci), the transcription factor that mediates outputs of Hh signal transduction, and we analyzed transcription profiles of control and mutant embryos to identify genes that are regulated by Hh. Putative targets we identified include several Hh pathway components, most previously identified targets, and many targets that are novel. Analysis of expression patterns of pathway components and target genes gave evidence of autocrine Hh signaling in the optic primordium of the embryo. And, every Hh target we analyzed that is not a pathway component appeared to be regulated by Hh in a tissue-specific manner. We present evidence that Hh-dependent

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Brian Biehs 

PROVIDER: E-GEOD-23999 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress