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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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NF-kB suppresses genomic instability in non-Hodgkin lymphomas

ABSTRACT: Oci-Ly3 and Daudi cell lines expressing p100-, p105- and luciferase-siRNA were used to identify genes that are regulated by p100 or p105 in each cell line. p100- (n=3) and p105- (n=3) expressing cells were compared to Luciferase siRNA, using linear models and signficant genes were identified using FDR of 0.001. Then the results for Daudi and OCI-LY3 cell lines were compared and only genes commonly regulated in both cell lines by p100 or p105 were selected for furhter studies.

ORGANISM(S): Homo sapiens

SUBMITTER: Xiangxue Guo

PROVIDER: E-GEOD-24020 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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NF-kB suppresses genomic instability in non-Hodgkin lymphomas

Project description:Oci-Ly3 and Daudi cell lines expressing p100-, p105- and luciferase-siRNA were used to identify genes that are regulated by p100 or p105 in each cell line.

2010-09-10 | GSE24020 | GEO

SPIB and BATF provide alternate determinants of IRF4 occupancy in Diffuse Large B-cell Lymphoma linked to disease heterogeneity

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SPIB and BATF provide alternate determinants of IRF4 occupancy in Diffuse Large B-cell Lymphoma linked to disease heterogeneity

Project description:ChIP-seq data for the transcription factors (TFs) IRF4, PU.1 and SPIB from the cell lines OCI-LY3, OCI-LY10 and H929, and BATF from the cell lines OCI-Ly3 and OCI-Ly10. In addition ChIP-seq for the TFs IRF4, PU.1 and SPIB from the cell line OCI-LY3 following transfections of scramble/SPIB-siRNA. ChIP-seq data for the transcription factors (TFs) IRF4, PU.1 and SPIB from the cell lines OCI-LY3, OCI-LY10 and H929, and BATF from the cell lines OCI-Ly3 and OCI-Ly10. In addition ChIP-seq for the TFs IRF4, PU.1 and SPIB from the cell line OCI-LY3 following transfections of scramble/SPIB-siRNA.

2014-06-03 | E-GEOD-56857 | biostudies-arrayexpress

Gene expression profiling of FOXP1-silenced diffuse large B-cell lymphoma (DLBCL) cell lines

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Project description:To identify differentially expressed genes regulated by FOXP1 in DLBCL cells via gene expression profiling of GCB-DLBCL (DB, K422) and ABC-DLBCL (OCI-Ly3, HBL-1) cell lines treated with siRNA targeting FOXP1 or non-silencing siRNA control. Two GCB-DLBCL (DB, K422) and two ABC-DLBCL (OCI-Ly3, HBL-1) cell lines were each treated separately with two independent siRNA oligonucleotides targeting FOXP1 (siFOXP1_308, siFOXP1_309) or non-silencing siRNA (siCtrl). Biological replicates derived from three independent experiments were obtained, RNA-extracted and subsequently hybridized into a human microarray platform for gene expression profiling.

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Methylation status of OCI Ly3 SP vs. nonSP

Project description:Promotor methylation status of Side Population cells of DLBCL cell line OCI Ly3 was compared to non Side Population Cells of OCI Ly3

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2013-12-07 | E-GEOD-53043 | biostudies-arrayexpress

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