Site-specific heterogeneity of melanocytes in human skin

ABSTRACT: Little is known about the mechanisms underlying the localization of human melanocytes during embryogenesis, and how the characteristics of melanocytes differ in various body sites. Immunohistochemical studies of biopsy tissue obtained from four different anatomic sites (scalp, back, abdomen, and sole) of 31 aborted fetuses following the approval of the ethics committee for the study of human gene analysis revealed that the melanocyte-associated marker gp100 was expressed earlier in embryogenesis than other melanocyte markers. Human fetal melanocytes are initially localized in the epidermis, and then migrate to the hair buds from the epidermis but not the dermis. In the sole, melanocytes localize in eccrine sweat gland ducts. Cultured fetal melanocytes did not stain positively for any melan

ORGANISM(S): Homo sapiens

SUBMITTER: Motoki Nakamura 

PROVIDER: E-GEOD-24041 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress