Comparison of gene expression profiles of HIV-specific CD8 T cells from controllers and progressors

ABSTRACT: CD8+ T cells in chronic viral infections like HIV develop functional defects such as loss of IL-2 secretion and decreased proliferative potential that are collectively termed exhaustion1. Exhausted T cells express increased levels of multiple inhibitory receptors, such as Programmed Death 1 (PD-1). PD-1 inhibition contributes to impaired virus-specific T cell function in chronic infection because antibody-mediated blockade of its ligand, Programmed Death Ligand 1 (PD-L1) is sufficient to improve T cell function and reduce viral replication in animal models. Reversing PD-1 inhibition is therefore an attractive therapeutic target, but the cellular mechanisms by which PD-1 ligation results in T cell inhibition are not fully understood. PD-1 is thought to limit T cell activation by attenuat

ORGANISM(S): Homo sapiens

SUBMITTER: W Haining 

PROVIDER: E-GEOD-24081 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress