Sall3 controls cone photoreceptor and horizontal cell differentiation

ABSTRACT: Transcription factors have been implicated in the specification and differentiation of all cells in the mammalian retina with several transcription factors controlling the development of multiple neuronal subclasses. Horizontal cells and cone photoreceptors share a particularly intimate functional relationship but have been previously thought to develop through separate and distinct intrinsic molecular processes. We demonstrate that the zinc finger transcription factor Sall3 regulates development of both S-cone photoreceptors and horizontal cells. Our data shows that loss of function of Sall3 down-regulates the horizontal cell specific transcription factor Lhx1 and subsequently causes ectopic formation of horizontal-like wide-field amacrine cells partially phenocopying Lhx1-/- mice. Ad

ORGANISM(S): Mus musculus

SUBMITTER: Seth Blackshaw 

PROVIDER: E-GEOD-24083 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress