Alterations in the Brain Transcriptome in Plasmodium Berghei ANKA Infected Mice

ABSTRACT: We have used cDNA microarrays to compare gene expression profiles in brains from normal mice to those infected with the Anka strain of Plasmodium berghei, a model of cerebral malaria. For each of three brains in each group, we computed ratios of all quantifiable genes with a composite reference sample and then computed ratios of gene expression in infected brains with untreated controls. Of the almost 12,000 unigenes adequateluy quantified in all arrays, about 3% were significantly downregulated (p<0.05, >50% fold change) and about 7% were upregulated. Upon inspection of the lists of regulated genes, we identified a high number encoding proteins of importance to normal brain function or associated with neuropathology. These results emphasize the important impact of malarial infection o

ORGANISM(S): Mus musculus

SUBMITTER: Dumitru Iacobas 

PROVIDER: E-GEOD-24086 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress