Identification of a neuronal gene expression signature: Role of cell-cycle arrest in murine neuronal differentiation in vitro

ABSTRACT: Stem cells are a potential key strategy for treating neurodegenerative diseases in which the generation of new neurons is critical. A better understanding of the characteristics and molecular properties of neural stem cells (NSC) and differentiated neurons can help in assessing neuronal maturity and possibly in devising better therapeutic strategies. We have therefore performed an in-depth gene expression profiling study of the C17.2 NSC line and primary neurons (PN) derived from embryonic mouse brains. Microarray analysis revealed a neuron-specific gene expression signature that distinguishes PN from NSCs, with elevated levels of transcripts involved in neuronal functions such as neurite development, axon guidance, in PN. The same comparison revealed decreased levels of multiple cytokine

ORGANISM(S): Mus musculus

SUBMITTER: Dan Zhou 

PROVIDER: E-GEOD-24116 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress