DC response to Respiratory syncytial virus from adult peripheral and cord blood

ABSTRACT: Respiratory syncytial virus (RSV) is a major cause of morbidity and mortality. Previous studies have suggested that T cell responses may contribute to RSV immunopathology, which could be driven by dendritic cells (DCs). DCs are productively infected by RSV, and during RSV infections, there is an increase of DCs in the lungs with a decrease in the blood. Pediatric populations are particularly susceptible to severe RSV infections, however DC responses to RSV from pediatric populations have not been examined. In this study, primary isolated DCs from cord blood and adult peripheral blood were compared after RSV-infection. Transcriptional profiling and biological network analysis identified transforming growth factor (TGF)-b and associated signaling molecules as differentially regulated in the

ORGANISM(S): Homo sapiens

SUBMITTER: James Crowe 

PROVIDER: E-GEOD-24132 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress