Transcription profiling of human leukemia cell lines treated with sera from Type I diabetes patients to investigate sera-induced transcriptional signatures.

ABSTRACT: Inflammation is common to many disorders and responsible for tissue and organ damage. However, the associated peripheral cytokine milieu is frequently dilute and difficult to measure, necessitating development of more sensitive and informative biomarkers for mechanistic studies, earlier diagnosis, and monitoring therapeutic interventions. Previously, we have shown that sera from type 1 diabetes (T1D) patients induces a unique disease-specific pro-inflammatory transcriptional profile in fresh peripheral blood mononuclear cells (PBMCs) compared to sera of healthy controls. To address the potential variance introduced by heterogeneity in responsiveness of PBMCs from different donors, we evaluated human leukemia cell lines as surrogates for fresh PBMCs. Expression signatures of 7 different ce

ORGANISM(S): Homo sapiens

SUBMITTER: Martin Hessner 

PROVIDER: E-GEOD-24147 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress