Transcription profiling of macrophages derived from WT and Vdr dificient mice after stimulation with IFNgamma and/or 1alpha,25(OH)2D3 to study molecular mechanisms of macrophage activation
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Robert Geffers
PROVIDER: E-GEOD-2421 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation.
Helming Laura L Böse Jens J Ehrchen Jan J Schiebe Stefanie S Frahm Thomas T Geffers Robert R Probst-Kepper Michael M Balling Rudi R Lengeling Andreas A
Blood 20050823 13
1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3), the activated vitamin D3 hormone, is a key regulator of calcium homeostasis and thereby indispensable for bone metabolism. In addition, 1alpha,25(OH)2D3 is known to mediate predominantly immunosuppressive responses in vitro and in vivo. It has been demonstrated that macrophages can produce 1alpha,25(OH)2D3 on activation with interferon gamma (IFN-gamma), although little is understood about the biologic significance of this response. We show here ...[more]
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