Seq-SDQ3891_LEM2_N2_MXemb

ABSTRACT: modENCODE_submission_3168 Although C. elegans was the first multicellular organism with a completely sequenced genome, how this genome is arranged within the nucleus is not known. By chromatin immunoprecipitation of the nuclear transmembrane protein LEM-2, we determined the regions of the C. elegans genome associated with the nuclear membrane. We found that large regions of several megabases on the left and right arms of each autosome were associated with the nuclear membrane. The center of each autosome was free of such interactions, suggesting these regions are largely looped out from the nuclear membrane. The X chromosome, unlike the autosomes, was associated with the nuclear membrane only at its left end. At a finer scale, these large membrane-associated domains consist of smaller subd

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Everett Zhou 

PROVIDER: E-GEOD-24241 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress