Orientsia tsutsugamushi stimulates an original gene expression program in human monocytes: relationship with gene expression in patients with scrub typhus

ABSTRACT: Orientia tsutsugamushi, an obligate intracellular bacterium, is the causative agent of scrub typhus. As O. tsutsugamushi is detected in circulating monocytes during acute phase of scrub typhus, we wondered if this organism was able to infect monocytes. We showed here that O. tsutsugamushi replicated in monocytes from healthy donors. Using human whole genome microarrays, we found that O. tsutsugamushi the expression of genes in which up-regulated and down-modulated genes were equally distributed. , the expression of type I interferon, interferon-stimulated genes and M1-associated genes was significantly up-regulated. Second, O. tsutsugamushi the expression of apoptosis-related genes and induced cell death in monocytes. Live organisms were indispensable to type I interferon response and apop

ORGANISM(S): Homo sapiens

SUBMITTER: adil ef 

PROVIDER: E-GEOD-24247 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress