Differential early pathogenic changes in human ileal gene expression in Crohn's disease and ulcerative colitis

ABSTRACT: The aim of this study is to identify early pathogenic changes in ileal gene expression that precede the development of macroscopic disease in inflammatory bowel diseases (IBDs). We focused on two IBD phenotypes that were unlikely to overlap: 1) ileal Crohn’s disease (CD) patients undergoing initial ileocolic resection of diseased ileum; and 2) ulcerative colitis (UC) patients undergoing total colectomy. The Control patients were those patients without IBD undergoing initial right hemicolectomy or total colectomy. In order to identify early pathogenic changes in the human ileum in inflammatory bowel diseases, we analyzed 99 two-color whole human genome expression profiles (Agilent 4410A) of a test human ileal cRNA probe vs. a common reference human ileal RNA from a Control patient (N17)

ORGANISM(S): Homo sapiens

SUBMITTER: Tianyi Zhang 

PROVIDER: E-GEOD-24287 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress