Sural nerve of progressive and non-progressive diabetic neuropathy patients

ABSTRACT: Diabetic neuropathy (DN) is a common complication of diabetes. While multiple pathways are implicated in the pathophysiology of DN, there are no specific treatments for DN and currently it is not possible to predict DN onset or progression. To examine gene expression signatures related to DN, microarray experiments were performed on a subset of human sural nerves collected during a 52-week clinical trial of acetyl-L-carnitine. A series of bioinformatics analyses analyzed differential gene expression and identified gene networks and pathways potentially responsible for the progression of DN. We identified 532 differentially expressed genes (DEGs) between patient samples with progressing or non-progressing DN, which were functionally enriched in pathways involving defense and inflammatory r

ORGANISM(S): Homo sapiens

SUBMITTER: Junguk Hur 

PROVIDER: E-GEOD-24290 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress