Expression profile of subcutaneous adipose samples from subjects at the time of Roux en Y gastric bypass surgery.

ABSTRACT: To map the genetics of gene expression in metabolically relevant tissues and investigate the diversity of expression SNPs (eSNPs) in multiple tissues from the same individual, we collected four tissues from approximately 1,000 patients undergoing Roux-en-y gastric bypass and clinical traits associated with their weight loss and co-morbidities. We then performed high-throughput genotyping and gene expression profiling and carried out a genome-wide association analyses for more than one hundred thousand gene expression traits representing four metabolically relevant tissues; liver, subcutaneous adipose, omental adipose and stomach. We successfully identified 24,531 eSNPs corresponding to ~10,000 distinct genes. This represents the greatest number of eSNPs identified to our knowledge by any s

ORGANISM(S): Homo sapiens

SUBMITTER: Radu Dobrin 

PROVIDER: E-GEOD-24297 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress