Differential pulmonary gene expression in a nonhuman primate model of HIV-related COPD

ABSTRACT: HIV-infected persons are at increased risk for developing pulmonary diseases including chronic obstructive pulmonary disease (COPD), and the fungal opportunistic pathogen, Pneumocystis jirovecii (Pc) has been implicated in the pathogenesis of HIV-related COPD. We previously developed a non-human primate model of HIV-related COPD using simian-human immunodeficiency virus (SHIV) and Pc co-infection in cynomolgus macaques. In the present study we examined gene expression profiles in lung tissue from SHIV/Pc co-infected monkeys with COPD and compared them to SHIV-infected monkeys infected with normal lung function. Microarray technology was used to develop gene profiles, and differential gene expression was determined by a comparative evaluation of competing normalization methods applied to

ORGANISM(S): Macaca fascicularis

SUBMITTER: Haiwen Shi 

PROVIDER: E-GEOD-24343 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress