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Transcription profiling of human Awells B-lymphoblastoid cell line after 6 h and 24 h of starvation-induced autophagy

ABSTRACT: Assessment of mRNA expression changes in the B-lymphoblastoid cell line Awells after 6 h and 24 h of starvation-induced autophagy

ORGANISM(S): Homo sapiens

SUBMITTER: Oliver Schoor

PROVIDER: E-GEOD-2435 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Autophagy promotes MHC class II presentation of peptides from intracellular source proteins.

Dengjel Jörn J Schoor Oliver O Fischer Rainer R Reich Michael M Kraus Marianne M Müller Margret M Kreymborg Katharina K Altenberend Florian F Brandenburg Jens J Kalbacher Hubert H Brock Roland R Driessen Christoph C Rammensee Hans-Georg HG Stevanovic Stefan S

Proceedings of the National Academy of Sciences of the United States of America 20050513 22

MHC-peptide complexes mediate key functions in adaptive immunity. In a classical view, MHC-I molecules present peptides from intracellular source proteins, whereas MHC-II molecules present antigenic peptides from exogenous and membrane proteins. Nevertheless, substantial crosstalk between these two pathways has been observed. We investigated the influence of autophagy on the MHC-II ligandome and demonstrated that peptide presentation is altered considerably upon induction of autophagy. The prese ...[more]

PMID: 15894616

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