Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Identification of Gene Products Involved in the Oxidative Stress Response of Moraxella catarrhalis: Evaluation of OxyR dependent Genes

ABSTRACT: Series of DNA microarrays (4) comparing the M. catarrhalis strain 035E and M. catarrhalis oxyR mutant response to 50 mM hydrogen peroxide. Wild-type cells and oxyR mutant cells were exposed to 50 mM hydrogen peroxide for 15 minutes. RNA was extracted and DNA microarray analysis performed. 4 biologic replicates were studied. One dye swap was included in this series analysis. Control oxyR mutant cells exposed to water

ORGANISM(S): Moraxella catarrhalis

SUBMITTER: Todd Hoopman

PROVIDER: E-GEOD-24351 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of gene products involved in the oxidative stress response of Moraxella catarrhalis.

Hoopman Todd C TC Liu Wei W Joslin Stephanie N SN Pybus Christine C Brautigam Chad A CA Hansen Eric J EJ

Infection and immunity 20101122 2

Moraxella catarrhalis is subjected to oxidative stress from both internal and environmental sources. A previous study (C. D. Pericone, K. Overweg, P. W. Hermans, and J. N. Weiser, Infect. Immun. 68:3990-3997, 2000) indicated that a wild-type strain of M. catarrhalis was very resistant to killing by exogenous hydrogen peroxide (H₂O₂). The gene encoding OxyR, a LysR family transcriptional regulator, was identified and inactivated in M. catarrhalis strain O35E, resulting in an increase in sensitivi ...[more]

PMID: 21098105

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Dataset Information

Identification of Gene Products Involved in the Oxidative Stress Response of Moraxella catarrhalis: Evaluation of OxyR dependent Genes

Publications

Identification of gene products involved in the oxidative stress response of Moraxella catarrhalis.

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