Gene array analysis of human CD34+ hematopoietic cells exposed during 24h to HOXB4 or HOXC4 homeoproteins

ABSTRACT: At the molecular level, the mechanisms of action of Hox genes during hematopoiesis remain elusive. Although reports have described the implication of Hox genes in some molecular pathways in mice, the targets of HOX proteins in human hematopoietic cells are mostly unidentified. Since HOXB4 and HOXC4 are transcription factors encoded by paralogous genes that display similar effects on HSCs and progenitors, we presumed that HOXB4 and HOXC4 regulate the same target genes during human HSC expansion. This hypothesis was supported by the fact that HOXB4 and HOXC4 have similar molecular structure and similar roles and expression patterns during development. To identify early factors and signaling pathways involved in hematopoietic cell expansion consecutive to the action of HOXB4 or HOXC4, we per

ORGANISM(S): Homo sapiens

SUBMITTER: Cathy Philippe 

PROVIDER: E-GEOD-24379 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress