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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human androgen-dependent and androgen-independent primary prostate cancer tumors

ABSTRACT: Affymetrix U133A comparison of two groups (10 samples each): untreated (androgen-dependent) primary prostate cancer (Gleasons 5-9) and androgen-independent primary prostate cancer. All samples were microdissected for tumor cells only.

ORGANISM(S): Homo sapiens

DISEASE(S): androgen-dependent prostate cancer

SUBMITTER: Carolyn Best

PROVIDER: E-GEOD-2443 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular alterations in primary prostate cancer after androgen ablation therapy.

Best Carolyn J M CJ Gillespie John W JW Yi Yajun Y Chandramouli Gadisetti V R GV Perlmutter Mark A MA Gathright Yvonne Y Erickson Heidi S HS Georgevich Lauren L Tangrea Michael A MA Duray Paul H PH González Sergio S Velasco Alfredo A Linehan W Marston WM Matusik Robert J RJ Price Douglas K DK Figg William D WD Emmert-Buck Michael R MR Chuaqui Rodrigo F RF

Clinical cancer research : an official journal of the American Association for Cancer Research 20051001 19 Pt 1

<h4>Purpose</h4>After an initial response to androgen ablation, most prostate tumors recur, ultimately progressing to highly aggressive androgen-independent cancer. The molecular mechanisms underlying progression are not well known in part due to the rarity of androgen-independent samples from primary and metastatic sites.<h4>Experimental design</h4>We compared the gene expression profiles of 10 androgen-independent primary prostate tumor biopsies with 10 primary, untreated androgen-dependent tu ...[more]

PMID: 16203770

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