Heart Transplant Rejection Profiling in Peripheral Blood
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mario Deng
PROVIDER: E-GEOD-2445 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling.
Deng M C MC Eisen H J HJ Mehra M R MR Billingham M M Marboe C C CC Berry G G Kobashigawa J J Johnson F L FL Starling R C RC Murali S S Pauly D F DF Baron H H Wohlgemuth J G JG Woodward R N RN Klingler T M TM Walther D D Lal P G PG Rosenberg S S Hunt S S
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060101 1
Rejection diagnosis by endomyocardial biopsy (EMB) is invasive, expensive and variable. We investigated gene expression profiling of peripheral blood mononuclear cells (PBMC) to discriminate ISHLT grade 0 rejection (quiescence) from moderate/severe rejection (ISHLT > or = 3A). Patients were followed prospectively with blood sampling at post-transplant visits. Biopsies were graded by ISHLT criteria locally and by three independent pathologists blinded to clinical data. Known alloimmune pathways a ...[more]
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