Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from human MSI colorectal cancer and normal colonic mucosa


ABSTRACT: Microsatellite instability (MSI), caused by defective mismatch repair, is observed in a subset of colorectal cancers (CRCs). We evaluated somatic mutations in microsatellite repeats of genes chosen based on reduced expression in MSI CRC and existence of a coding mononucleotide repeat. Expression profiling of 34 MSI colorectal cancers and 15 normal colonic mucosas was performed in 2002. Comparison of malignant and healthy tissue.

ORGANISM(S): Homo sapiens

SUBMITTER: Pia Vahteristo 

PROVIDER: E-GEOD-24514 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Defects in the mismatch repair system lead to microsatellite instability (MSI), a feature observed in ∼ 15% of all colorectal cancers (CRCs). Microsatellite mutations that drive tumourigenesis, typically inactivation of tumour suppressors, are selected for and are frequently detected in MSI cancers. Here, we evaluated somatic mutations in microsatellite repeats of 790 genes chosen based on reduced expression in MSI CRC and existence of a coding mononucleotide repeat of 6-10 bp in length. All the  ...[more]

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