Polycomb preferentially targets stalled promoters of coding and non-coding transcripts

ABSTRACT: The Polycomb group (PcG) and Trithorax group (TrxG) of proteins are required for stable and heritable maintenance of repressed and active gene expression states. Their antagonistic function on gene control, repression for PcG and activity for TrxG, is mediated by binding to chromatin and subsequent epigenetic modification of target loci. Despite our broad knowledge about composition and enzymatic activities of the protein complexes involved, our understanding still lacks important mechanistic detail and a comprehensive view on target genes. In this study, we use an extensive data set of ChIP-seq, RNA-seq, and genome-wide detection of transcription start sites (TSSs) to identify and analyze thousands of binding sites for the PcG proteins and Trithorax from a Drosophila S2 cell line. In addi

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Daniel Enderle 

PROVIDER: E-GEOD-24521 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress