Expression data of SAGM-grown cells derived thyroid follicular cells

ABSTRACT: We developed a novel culture system to obtain multilineage undifferentiated stem/progenitor cells from normal human thyroid tissues. This seems to be achieved by direct reprogramming of thyroid follicular cells. The objective of the study was to reveal gene expression profile of the obtained cells compared to primary thyrocytes. After enzymatic digestion, primary thyrocytes, expressing thyroglobulin and cytokeratin-18, were cultured in a serum-free medium called SAGM containing insulin and EGF. Although the vast majority of cells died, a small proportion (~0.5%) survived and proliferated. During initial cell expansion, thyroglobulin/cytokeratin-18 expression was gradually declined, suggesting that those cells are derived from thyroid follicular cells or at least thyroid-committed cells. Th

ORGANISM(S): Homo sapiens

SUBMITTER: Norisato Mitsutake 

PROVIDER: E-GEOD-24553 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress