Comparison of gene expression in ventral prostates of 12 week old AR-E231G mice with AR-T857A mice

ABSTRACT: The androgen receptor (AR) is an androgen-activated nuclear receptor. The androgen signaling axis is critical in all stages of prostate cancer, although the mechanism by which it contributes to tumorigenesis remains unclear. Mutations in the AR have been detected in prostate tumors; one such mutant, E231G, exhibits increased ligand sensitivity in the presence of specific cofactors. Mice with prostate-specific expression of AR-E231G invariably develop prostatic intraepithelial neoplasia (PIN) by 12 weeks, and metastatic prostate cancer by 52 weeks. To determine a potential mechanism of AR-driven tumorigenesis in AR-E231G mice, we compared gene expression profiles in prostates of 12 week old AR-E231G mice with another AR-variant mouse strain (AR-T857A) that does not develop tumors. Pathw

ORGANISM(S): Mus musculus

SUBMITTER: Vanessa Thompson 

PROVIDER: E-GEOD-24567 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress