Estrogen regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation

ABSTRACT: Despite numerous observations of effects of estrogens on spermatogenesis, identification of estrogen-regulated genes in the testis is limited. We previously showed in rats, in which irradiation had completely blocked spermatogonial differentiation, that testosterone (T) suppression with GnRH-antagonist and antiandrogen stimulated spermatogenic recovery and addition of estradiol (E2) to this regimen accelerated this recovery. We report here the global changes in testicular cell gene expression induced by the E2 treatment. By minimizing the changes in other hormones and also having concurrent data on the regulation of the genes by those hormones, we were able to dissect the effects of estrogen on gene expression, independent of gonadotropin or T changes. Expression of 20 genes, largely in so

ORGANISM(S): Rattus norvegicus

SUBMITTER: Wei Zhou 

PROVIDER: E-GEOD-24672 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress