Transcription profiling of tungstate-induced beta cell mass increase in Rattus norvegicus subjects with induced diabetes

ABSTRACT: Background and Aims: It is well demonstrated that in the beta cell population of the pancreas there is a dynamic turnover, which results from the net balance of several processes; beta cell replication, apoptosis and neogenesis. These processes have been studied in partial pancreatectomy and glucagon-like peptide 1 treated animals, where an increase in pancreas regeneration has been observed. Similarly, sodium tungstate, which decreases hyperglycemia in several animal models of diabetes, promotes a rise in the beta cell mass of nSTZ and STZ animals. However, the molecular mechanisms underlying this pancreas regeneration remain unknown. Therefore the objective of this study is to identify which genes are up or down regulated in the increase of the beta cell population of STZ rats treated wi

ORGANISM(S): Rattus norvegicus

SUBMITTER: Jordi Altirriba 

PROVIDER: E-GEOD-2470 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress