Part 2/7: NTNeurons_24hpi_activevirus_dendrimer

ABSTRACT: Differentiated NT2 cells are a potentially useful model system to study herpes simples virus (HSV) replication in human neurons. These cells can be irreversibly differentiated into NT-neurons in the presence of retinoic acid and non-dividing cultures NT-neurons can be maintained for up to several months without retinoic acid. HSV is capable of infecting and replicating in differentiated NT-neurons and thus differentiated NT-neurons provide a ready source of human post-mitotic cells which can be useful to study certain aspects of the interaction of HSV and the neuron. Microarray analysis was used to examine how HSV-1 infection modulates cellular transcription in human NT-neurons, focusing on changes that take place during the first 24 hours following infection and compared to changes res

ORGANISM(S): Homo sapiens

SUBMITTER: Falko Schmeisser 

PROVIDER: E-GEOD-24719 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress