Gene expression differences between highly enriched normal and chronic myelogenous leukemia quiescent stem/progenitor cells and correlations with biological abnormalities

ABSTRACT: In comparing gene expression of normal and CML CD34+ quiescent (G0) and proliferating (G1/S/G2/M) cells, 292 genes were down-regulated and 192 genes were up-regulated in the CML G0 cells. The differentially expressed genes were grouped according to their reported functions and correlations were sought with biological differences previously observed between the same groups. The most apparent correlations include: i) Normal and CML G0 cells are more primitive than G1/S/G2/M cells; ii) CML G0 cells are in a more advanced stage of development and more poised to begin proliferating than normal G0 cells; iii) When CML G0 cells are stimulated to proliferate, they undergo further differentiation and maturation more rapidly than normal G0 cells, but both granulopoiesis and erythropoiesis are less e

ORGANISM(S): Homo sapiens

SUBMITTER: Qianxing Mo 

PROVIDER: E-GEOD-24739 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress