Molecular markers of predictive value associated with low birth weight

ABSTRACT: Sub-optimal fetal development is associated with an increased risk of developing cardiovascular disease, type 2 diabetes (T2D) and adiposity later in life. However, definitions of intrauterine growth restriction (IUGR) and small for gestational age (SGA) are based on simple statistical approaches that may misclassify infants with a normal developmental profile and vice versa. We used an unbiased global profiling approach to identify gene expression patterns in umbilical cord tissue from 38 infants and identified a set of 466 genes which separated the subjects into 2 distinct groups – one biased towards lower birth weight and one biased towards normal birth weight. The data suggest that approximately 30% of children of normal size have a molecular profile more typical of impaired fetal deve

ORGANISM(S): Homo sapiens

SUBMITTER: Emilia Tng 

PROVIDER: E-GEOD-24818 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress