Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes

ABSTRACT: LTB4, 50 nmol/L for 30 minutes, induced expression of 27 genes in cultured human elutriated monocytes comparred to vehicle (ethanol) treated control cells. Matched control versus treated cells

ORGANISM(S): Homo sapiens

SUBMITTER: Jennifer Barb 

PROVIDER: E-GEOD-24869 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes.

Chen L Y LY   Eberlein M M   Alsaaty S S   Martinez-Anton A A   Barb J J   Munson P J PJ   Danner R L RL   Liu Y Y   Logun C C   Shelhamer J H JH   Woszczek G G  

Allergy 20110524 10

<h4>Background</h4>Leukotriene B(4) (LTB(4)) and cysteinyl leukotrienes (cysLTs) are important immune mediators, often found concomitantly at sites of inflammation. Although some of the leukotriene-mediated actions are distinctive (e.g., bronchial constriction for cysLTs), many activities such as leukocyte recruitment to tissues and amplification of inflammatory responses are shared by both classes of leukotrienes.<h4>Objective</h4>We used human monocytes to characterize leukotriene-specific sig  ...[more]

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