Transcription profiling of cell lines produced from premalignant tumors with induced sensence

ABSTRACT: Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer.

ORGANISM(S): Homo sapiens

DISEASE(S): senescence induced

SUBMITTER: Manuel Collado 

PROVIDER: E-GEOD-2487 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress