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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling time series of cultured human keratinocytes treated with TNFalpha in the presence or absence of the NFkB inhibitor parthenolide

ABSTRACT: Cultured keratinocytes treated with TNFa in the presence or absence of NFkB inhibitor; time course 1, 4, 24 & 48 hrs.

ORGANISM(S): Homo sapiens

SUBMITTER: Miki Blumenberg

PROVIDER: E-GEOD-2489 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Pathway-specific profiling identifies the NF-kappa B-dependent tumor necrosis factor alpha-regulated genes in epidermal keratinocytes.

Banno Tomohiro T Gazel Alix A Blumenberg Miroslav M

The Journal of biological chemistry 20050218 19

Identification of tumor necrosis factor alpha (TNF alpha) as the key agent in inflammatory disorders led to new therapies specifically targeting TNF alpha and avoiding many side effects of earlier anti-inflammatory drugs. However, because of the wide spectrum of systems affected by TNF alpha, drugs targeting TNF alpha have a potential risk of delaying wound healing, secondary infections, and cancer. Indeed, increased risks of tuberculosis and carcinogenesis have been reported as side effects aft ...[more]

PMID: 15722350

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TNF & Parthenolide treatment of keratinocytes

Project description:Cultured keratinocytes treated with TNFa in the presence or absence of NFkB inhibitor; time course 1, 4, 24 & 48 hrs. Keywords = Epidermis Keywords = skin Keywords = keratinocytes Keywords = inflammation Keywords = NFkB Keywords = TNFa Keywords: time-course

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Tsirvouli2021 - Cytokine and eicosanoid signaling in psoriatic keratinocytes

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Transcription profiling of human epidermal keratinocytes treated with IFN-gamma reveals IFN-gamma suppressed the expression of over 100 genes responsible for cell cycle, DNA replication and RNA metabolism.

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