Response of A549 cells treated with Aspergillus fumigatus [WT-CF_vs_PrtT-CF]

ABSTRACT: Response of A549 cells treated with Aspergillus fumigatus wild type culture filtrate (WT-CF) or PrtT protease deficient mutant culture filtrate (PrtT-CF) for 8h Aspergillus fumigatus is the most commonly encountered mold pathogen of humans, predominantly infecting the respiratory system. Colonization and penetration of the lung alveolar epithelium is a key but poorly understood step in the infection process. This study focused on identifying the transcriptional and cell-signaling responses activated in A549 alveolar carcinoma cells incubated in the presence of A. fumigatus wild-type and ΔPrtT protease-deficient germinating conidia and culture filtrates (CF). Microarray analysis of exposed A549 cells identified distinct classes of genes whose expression is altered in the presence of germin

ORGANISM(S): Homo sapiens

SUBMITTER: Haim Sharon 

PROVIDER: E-GEOD-24985 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress