Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of murine leukemic T cells from Ikaros-deficient mice and wild type mice to identify critical gene expression events during T-cell leukemogenesis.

ABSTRACT: The experiment was to compare leukemic T cells from thymic lymphomas from homozygote mice for the IkL/L hypomorphic mutation and non-transformed thymocytes, either of WT or IkL/L genotype. The aim was to identify a gene expression signature specific to the IkL/L tumors.

ORGANISM(S): Mus musculus

DISEASE(S): wild type

SUBMITTER: Philippe Kastner 

PROVIDER: E-GEOD-2501 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice.

Dumortier Alexis A   Jeannet Robin R   Kirstetter Peggy P   Kleinmann Eva E   Sellars MacLean M   dos Santos Nuno R NR   Thibault Christelle C   Barths Jochen J   Ghysdael Jacques J   Punt Jennifer A JA   Kastner Philippe P   Chan Susan S  

Molecular and cellular biology 20060101 1

The Ikaros transcription factor is both a key regulator of lymphocyte differentiation and a tumor suppressor in T lymphocytes. Mice carrying a hypomorphic mutation (Ik(L/L)) in the Ikaros gene all develop thymic lymphomas. Ik(L/L) tumors always exhibit strong activation of the Notch pathway, which is required for tumor cell proliferation in vitro. Notch activation occurs early in tumorigenesis and may precede transformation, as ectopic expression of the Notch targets Hes-1 and Deltex-1 is detect  ...[more]

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